Yamaha's Valentino Rossi is aiming to find his end-of-race pace directly off the start line, as that looks to be the weak link stopping him from challenging for a podium or win once more. GO&FUN Honda Gresini's Alvaro Bautista, on the other hand, will be searching for a way past the famous Italian, having lost out to him narrowly in the last three races. LCR Honda MotoGP's Stefan Bradl has been somewhat off-colour at recent events, despite showing great pace over one lap. He will need to rediscover the race pace that saw him take second from pole position at Laguna Seca, whereas Monster Yamaha Tech3's Cal Crutchlow will look to forget his crash-plagued Silverstone and get back to challenging for the podium.
The Ducati Team duo may fare better at Misano than in previous outings, as they occasionally use it as a test track during the season, yet no doubt they will have Tech3's British rookie Bradley Smith to contend with, who has recently been tussling with the Ducatis on-track at numerous races to date in 2013. Ignite Pramac Racing's Ben Spies is once again replaced due to injury by Ducati test rider Michele Pirro, who will make it a fully Italian garage alongside Energy T.I. Pramac Racing's Andrea Iannone.
Power Electronics Aspar's Aleix Espargaro still looks near unstoppable as top CRT on his ART, while the likes of NGM Mobile Forward Racing's Colin Edwards and Avintia Blusens' Hector Barbera will have a tough job chasing him. The action begins with Free Practice 1 at 9:55am local time (GMT +2) on Friday.